Clinical Study
A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites
Table 2
Results for primary outcome measure, the mean square root of erythema area (SREA) at 1 hours and 24 hours post-bite.
| Outcome | Mean (SE) of SREA (mm) Mosquito antigen () | Mean (SE) of SREA (mm) Placebo () | Difference in mean SREA (drug-placebo)* (95% CI) | |
| Baseline | | | | | 1 hour | 31.3 (3.4) | 24.5 (3.2) | | | 24 hours | 33.7 (3.4) | 28.7 (2.3) | | | Followup | | | | | 1 hour | 27.4 (2.9) | 22.6 (3.2) | 0.46 (−6.11 to 7.03) | 0.89 | 24 hours | 35.1 (2.4) | 35.0 (2.9) | −2.58 (−11.73 to 6.57) | 0.57 | Proportion of participants with a decrease in SREA at | | | | | 1 hour | 14/24 (58%) | 12/25 (48%) | | | 24 hours | 8/24 (33%) | 9/25 (36%) | | |
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Adjusted for baseline values (ANCOVA analysis).
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