Breed-Predispositions to Cancer in Pedigree Dogs

Table 5

Comparative analysis of the role of critical genes and signalling pathways involved in the carcinogenesis of human breast cancer and canine mammary tumor.

	Human breast cancer	Canine mammary tumor
Gene sets/signaling pathways
P13K/AKT	Upregulation	Upregulation
KRAS	Upregulation	Upregulation
PTEN	Downregulation	Downregulation
Wnt*b catenin	Upregulation	Upregulation
MAPK cascade	Upregulation	Upregulation
BRCA1	Downregulation	Downregulation
BRCA2	Upregulation	Upregulation
P53	Downregulation	Downregulation

Table modified from Pinho et al., 2012 [7], and based mainly on data from Uva et al., 2009 [209].