|
| Germ layer | Tissue | Author and year | Reference | Model system |
|
| Mesoderm | | Hicok et al. 2004 | [185] | HA/TCP scaffolds + hASCs, subQ implantation, athymic mice |
| | Cowan et al. 2004 | [188] | HA/PLGA scaffolds + mASCs, cranial defects, mice |
| | Levi et al. 2010 | [190] | HA/PLGA scaffolds + hASCs, cranial defects, athymic mice |
| | Levi et al. 2011 | [189] | Intravenous administration of hASCs, cranial defects, athymic mice |
| | Dudas et al. 2006 | [197] | Gelatin foam + osteo-induced rabbit ASCs, BMP2 treatment, cranial defect, rabbits |
| | Yoon et al. 2007 | [193] | PLGA scaffolds + osteo-induced hASCs, cranial defect, athymic rats |
| Bone | Cui et al. 2007 | [186] | Coral scaffolds + osteo-induced canine ASCs, cranial defects, dogs |
| | Conejero et al. 2006 | [194] | PLA scaffolds + osteo-induced rASCs, palatal defects, rats |
| | Yang et al. 2005 | [198] | CNI scaffolds + rASCs, Ad-BMP7 transduction, subQ implantation, rats |
| | Sheyn et al. 2011 | [199] | Fibrin gels + porcine ASCs, BMP6 plasmid transfection, vertebral defects, athymic rats |
| | Chen et al. 2010 | [200] | Acellular bone matrix + porcine ASCs, BMP2 and VEGF plasmid transfection, ulnar defect, minipigs |
| | Lee et al. 2010 | [201] | PLGA scaffolds + hASCs, BMP2/Runx2 bicistronic plasmid transfection, subQ implantation, athymic mice |
| | Peterson et al. 2005 | [203] | CNI/ceramic scaffolds + hASCs, Ad-BMP2 transduction, femoral defects, athymic rats |
| | Chou et al. 2010 | [204] | HA/PLGA scaffolds + hASCs, BMP2 treatment, femoral defects, athymic rats |
| | Smith et al. 2011 | [207] | CNI scaffolds + rabbit ASCs, BMP2 treatment, cranial defects, rabbits |
| | Dragoo et al. 2003 | [208] | Fibrin glue + pre-induced hASCs, intramuscular implantation, athymic mice |
| | Jin et al. 2007 | [209] | Alginate scaffolds + TGF2-induced hASCs, subQ implantation, athymic mice |
| Cartilage | Mehlhorn et al. 2009 | [210] | PLGA scaffolds + TGF1-induced hASCs, subQ implantation, athymic mice |
| | Dragoo et al. 2007 | [212] | Fibrin glue + rabbit ASCs, full-thickness subchondral defects, rabbits |
| | Cui et al. 2009 | [213] | PGA scaffolds + pre-induced porcine ASCs, full-thickness subchondral defects, pigs |
| Fat | Hong et al. 2006 | [218] | Gelatin scaffolds + pre-induced hASCs, subQ implantation, athymic mice |
| Ito et al. (In press) | [220] | bFGF-coupled CN/gelatin scaffolds + hASCs, subQ implantation |
| Mizuno et al. 2008 | [217] | Fibrin glue + GFP+ve mASCs, subQ implantation, mice |
| Skeletal muscle | Rodriguez et al. 2005 | [229] | hASCs + mdx murine model, hMAD subpopulation |
| Goudenege et al. 2009 | [230] | hASCs + mdx murine model, hMAD subpopulation |
| Liu et al. 2007 | [231] | Pre-induced hASCs + mdx murine model |
| Vieira et al. 2008 | [232] | hASCs + limb girdle muscular dystrophy murine model, tail vein administration |
| Smooth muscle | Jack et al. 2005 | [104] | hASCs + bladder/urethral injection, athymic mice |
| Zhang et al. 2012 | [80] | hASC/bladder smooth muscle co-culture + bladder injection, athymic mice |
| Lin et al. 2010 | [234] | rASCs + SUI model, rats |
| Zhao et al. 2011 | [106] | rASCs + periurethral injection, PLGA/NGF microspheres, SUI model, rats |
| Zhao et al. 2012 | [236] | Rabbit ASCs + decellularized vessel grafts, ureter defect, rabbits |
| Zhu et al. 2010 | [237] | Rabbit ASCs + bladder acellular matrix grafts, bladder reconstruction, rabbits |
| Cardiac muscle | Mazo et al. 2008 | [247] | mASCs + MI model, athymic rats |
| Cai et al. 2009 | [249] | hASCs + MI model, athymic rats |
| Okura et al. 2012 | [241] | hASC-derived cardiomyoblasts + pig MI model |
| Léobon et al. 2009 | [246] | mASC-derived cardiomyocytes + murine MI model |
| Zhang et al. 2007 | [252] | Rabbit ASC-derived cardiomyocytes + rabbit MI model |
| Beitnes et al. 2012 | [244] | ASCs + intramyocardial injection, MI model, athymic rats |
| Zhang et al. 2010 | [248] | rASCs + rat MI model, injectable fibrin glue scaffolds |
| Yang et al. (In press) | [253] |
|
| Ectoderm | Nerve repair | Orbay et al. 2012 | [272] | Neural-induced ASCs + peripheral nerve gaps, rats, silicone conduits |
| Yang et al. 2011 | [261] | Neural induced rASCs + focal cerebral ischemia, rats |
| Park et al. 2012 | [267] | Neural induced canine ASCs + spinal cord injury, dogs, matrigel implants |
| Lopatina et al. 2011 | [279] | Neural induced mASCs + peroneal nerve injury, mice, matrigel implants |
| Tomita et al. 2012 | [269] | rASC-derived Schwann cells + nerve denervation model, rats |
| Chi et al. 2010 | [271] | rASC-derived Schwann cells + spinal cord injury, rats |
| Di Summa et al. 2010 | [273] | rASC-derived Schwann cells + sciatic nerve injury, fibrin conduits, rats |
| Wei et al. 2009 | [276] | rASC-conditioned media + ischemia model, rats |
| Zhang et al. 2010 | [282] | rASCs + xenogeneic acellular nerve matrices, sciatic nerve injury, rats |
| | Planat-Benard et al. 2004 | [150] | mASC/hASC + muscle vascularization and hindlimb ischemia, intramuscular injection, athymic mic |
| | Moon et al. 2006 | [297] | hASCs + hindlimb ischemia model, mice |
| | Miranville et al. 2004 | [300] | hASCs (CD34+/CD31−) + hindlimb ischemia model, athymic mice, IV administration |
| | Kim et al. 2011 | [303] | hASCs + ischemic limb wound, diabetic model, athymic mice, local injection |
| | Liu et al. 2011 | [304] | rASCs + pulmonary hypertension model, rats |
| | Gao et al. 2011
| [306] | hASCs + skin flaps, STZ-diabetic model, athymic mice, local injection |
| Endothelial-vascularization | Mazo et al. (In press) | [311] | Porcine ASCs + cardiac IR injury model, mini-pigs, trans-endocardial injection |
| | Sun et al. 2011 | [312] | rASCs + lung IR injury model, rats, IV administration |
| | Furuichi et al. 2012 | [313] | mASCs + kidney IR injury model, mice, IV administration |
| | Traktuev et al. 2009 | [317] | hASC + endothelial precursors, subQ implantation, athymic mice |
| | Matsumoto et al. 2006 | [224] | hASCs + lipoaspirate fat grafts, local administration |
|
| | Liver | Kim et al. 2003 | [254] | hASCs + partial hepatectomy, athymic mice, IV administration |
| | Ruiz et al. 2010 | [257] | hASCs + CCL4-induced liver injury, athymic mice |
| | Banas et al. 2008 | [258] | hASCs + CCL4-induced liver injury, athymic mice, IV administration |
| | Wang et al. 2010 | [255] | Pre-induced hASCs + PLGA scaffold implantation, hepatectomized rats |
| Endoderm | Harn et al. (In press) | [256] | Pre-induced hASCs + TAA-induced liver fibrosis model, rats, direction injection |
| | Banas et al. 2009 | [159] | Pre-induced hASCs + CCL4-induced liver injury, athymic mice |
| | Pancreas | Timper et al. 2006 | [151] | Pancreatic induction medium |
| | Chandra et al. 2009 | [152] |
| | Lee et al. 2008 | [154] | Pancreatic extract |
|
