Study Type of study Study comments (OR, RR, HR)1 Adjusted variables Results Barb et al. [18 ] Case-control 102 women with breast cancer/100 healthy women OR Age, family history, menarche age, BMI, menopause age, marriage status An inverse relationship between adiponectin levels and breast cancer pre- and post menopause Jardé et al. [17 ] Case-control 70 women with breast cancer/28 healthy women 25–65 years old OR Employment status, age at first pregnancy, smoking, alcohol consumption, OCP, hormone therapy, family history, breastfeeding, BMI Inverse relationship between hormone concentration and breast cancer in pre- and postmenopause/abdominal obesity and physical inactivity increase the risk of cancer Cust et al. [29 ] Case-control 174 women with breast cancer/167 healthy women OR IGF Components, leptin, BMI, and socio- economic variables Inverse relationship between adiponectin concentration and breast cancer in postmenopausal women Otake et al. [30 ] Prospective case-control 1477 women with breast cancer/2196 healthy women RR2 3 Age, menopausal status, postmenopausal hormone use No significant correlation between hormone levels and cancer risk Tian et al. [1 ] Hospital-based 244 women with breast cancer/244 healthy women OR3 Age, BMI, waist to hip ratio No significant correlation between hormone levels and risk of breast cancer in premenopause and a significant associated with breast cancer hormone in postmenopause Kaklamani et al. [25 ] Hospital-based Case-control 74 healthy women/74 women with breast cancer OR Age, BMI, age at menarche, menopausal status, family history, insulin and leptin 0.77 Reduction in the cancer risk in women who were at the highest quartile of adiponectin levels Körner et al. [26 ] Prospective 248 women with endometrial cancer and 548 healthy women RR BMI Stronger relationship between hormones and the risk of endometrial cancer in obese women Tworoger et al. [31 ] Case-control 87 women with endometrial cancer/132 healthy women OR4 Age, education, marriage status, smoking status, BMI, hormone replacement therapy High energy intake and low adiponectin associated with increased risk of endometrial cancer Treeck et al. [32 ] Case control 117 women with endometrial cancer and 238 healthy women OR Age, BMI, diabetes, high blood pressure 11-fold increased risk of endometrial cancer in people who were at the lowest level of adiponectin compared with the highest level Dal Maso et al. [33 ] Case control 84 women with endometrial cancer/84 healthy women OR IGF, leptin, BMI, demographic-social variables 1 standard deviation increased adiponectin levels decreased 50% risk of breast cancer in women younger than 65 years old. No significant association was found in individuals older than 65 years Soliman et al. [34 ] Nested case-control 698 men with BPH/ 705 healthy men OR BMI, alcohol consumption, age People with the highest hormone concentration were in 35% lower risk for BPH Körner et al. [26 ] Case control 75 men with prostatic cancer/75 men with BPH/150 healthy men OR Age, BMI, alcohol consumption, smoking 73% lower risk of prostate cancer in those in the highest quartile hormone levels compared with those who were in the lowest quartile Petridou et al. [35 ] Prospective 645 men with prostatic cancer and 644 healthy men HR BMI, peptide C, type and grade Inverse relationship between sex hormones and fatal prostate cancer (comparing quintile 1 and 5) He et al. [36 ] Case-control 30 healthy people and 62 patients with esophageal cancer — — Low adiponectin levels in cancer patients (
) Beebe-Dimmer et al. [37 ] Nested case-control 381 people with colorectal cancer and 381 healthy people — — No significant correlation between serum adiponectin levels and colorectal cancer Yıldırım et al. [38 ] Nested case-control 311 male cases with pancreatic cancer, 50–69 years old/510 control subjects OR Smoking status, blood pressure, C-peptide The lower the cancer risk in people who were in the highest quintile of serum hormone Goktas et al. [39 ] Prospective 18225 men in total that 179 of whom were diagnosed with colorectal cancer, aged 40–75 years RR BMI Significant correlation between hormone levels and cancer risk—no significant relationship was observed after adjustment for potential confounding Kaklamani et al. [40 ] Case-control 420 people with colorectal cancer and 555 healthy people OR Age, sex Significant relationship between adiponectin R1 receptor and risk of colorectal cancer Stolzenberg-Solomon et al. [41 ] Case-control 81 people with pancreatic cancer and 81 healthy people OR Age, sex, BMI, smoking status, alcohol intake, history of diabetes, leptin Positive and significant correlation between hormone concentrations and risk of pancreatic cancer
