Research Article

A Novel Vaccine Using Nanoparticle Platform to Present Immunogenic M2e against Avian Influenza Infection

Table 1

Summary of self-assembling nanoparticle peptide sequences.

Construct namePeptide sequence

Mono-M2e126794.table.001a

Tetra-M2e126794.fig.0013

M2e-GCN4126794.fig.0014

M2e126794.fig.0015

The peptide Mono-M2e is composed of a pentameric coiled coil (green) and a trimeric coiled coil (blue). Tetra-M2e uses the same trimer but has a tetrameric coiled coil (turquoise). In both sequences, the M2e epitope is shown in red. Other amino acid residues, such as linkers and his-tags, are shown in black. M2eN-GCN4 consists of M2e attached to the tetrameric GCN4 coiled coil, shown in brown. Monomeric M2e, used for ELISA, coating is shown in red.