Association of IFNAR2 rs2236757 and OAS3 rs10735079 Polymorphisms with Susceptibility to COVID-19 Infection and Severity in Palestine

Table 5

Association of IFNAR2 rs2236757 and OAS3 rs10735079 polymorphisms with COVID-19 signs and symptoms in all patients.

rs2236757 (IFNAR2)		Yes	No.	OR (95% CI)	value
Sore throat	Codominant^†
	GG	13	32	ref	0.011
	GA	23	25	2.52 (1.02–6.24)
	AA	0	6	0.0 (0.0- NA)
	Dominant
	GG	13	32	ref	0.124
	GA + AA	23	31	1.98 (0.82–4.76)
	Recessive
	GG + GA	36	57	ref	0.026
	AA	0	6	0.0 (0.0- NA)
	Over dominant
	GG + AA	13	38	ref	0.018
	GA	23	25	2.89 (1.18–7.13)
	Log additive
		36	63	1.25 (0.61–2.57)	0.538
Dyspnea	Codominant
	GG	16	29	ref	0.002
	GA	29	20	4.28 (1.57–11.71)
	AA	6	0	NA
	Dominant
	GG	16	29		0.001
	GA + AA	35	20	4.81 (1.77–13.09)
	Recessive
	GG + GA	45	49	ref	0.054
	AA	6	0	NA
	Over dominant
	GG + AA	22	29	ref	0.009
	GA	29	20	3.49 (1.32–9.25)
	Log additive^†
		51	49	4.70 (1.80–12.27)	<0.001
rs10735079 (OAS3)		Yes	No	OR (95% CI)	value
Sore throat	Codominant
	GG	15	17	ref	0.004
	GA	17	20	0.88 (0.33–2.38)
	AA	4	26	0.16 (0.04–0.58)
	Dominant
	GG	15	17	ref	0.099
	GA + AA	21	46	0.47 (0.19–1.16)
	Recessive^†
	GG + GA	32	37	ref	<0.001
	AA	4	26	0.17 (0.05–0.55)
	Over dominant
	GG + AA	19	43	ref	0.162
	GA	17	20	1.86 (0.78–4.45)
	Log additive
		36	63	0.44 (0.24–0.79)	0.004
Muscle aches	Codominant
	GG	22	10	ref	0.079
	GA	27	11	1.11 (0.38–3.22)
	AA	14	16	0.36 (0.12–1.09)
	Dominant
	GG	22	10	ref	0.394
	GA + AA	41	27	0.67 (0.26–1.70)
	Recessive^†
	GG + GA	49	21	ref	0.0248
	AA	14	16	0.34 (0.13–0.88)
	Over dominant
	GG + AA	36	26	ref	0.191
	GA	27	11	1.81 (0.74–4.47)
	Log additive
		63	37	0.60 (0.34–1.05)	0.068

^†Best model to explain the association according to the Akaike information criterion. The odds ratios and the values were from logistic regression models adjusted for age, gender, smoking history, history of hypertension, diabetes mellitus, and coronary artery disease. After Bonferroni correction, a value <0.025 was considered significant. OR, odds ratio; ref, reference; NA, not applicable. values below the significance threshold are highlighted in bold