Interdisciplinary Perspectives on Infectious Diseases / 2023 / Article / Tab 3 / Review Article
Aptamer-Based Strategies to Address Challenges in COVID-19 Diagnosis and Treatments Table 3 List of high-affinity ssDNA and RNA aptamers targeting the S protein, RBD of the S protein, N protein, or ACE2 protein isolated using different SELEX protocols as potential therapeutic agents for COVID-19.
Target Types Aptamer sequence (5′-3′) Randomization region length (bp) K D (nM)Partitioning method Selection pool regeneration method References S Protein ssDNA GGGAGAGGAGGGAGATAGATATCAACCCATGGTAGGTATTGCTTGGTAGGGATAGTGGGCTTGATGTTTCGTGGATGCCACAGGAC 40 21 ± 4.6 Bead Lambda exonuclease digestion Schmitz et al. [7 ] S Protein ssDNA ATCCAGAGTGACGCAGCATCGAGTGGCTTGTTTGTAATGTAGGGTTCCGGTCGTGGGTTGGACACGGTGGCTTAGT 40 28 Bead — Liu et al. [6 ] SRBD ssDNA CGCAGCACCCAAGAACAAGGACTGCTTAGGATTGCGATAGGTTCGG — 44.78 ± 9.97 Bead — Sun et al. [8 ] SRBD RNA GATCCATGGGCACTATTTATATCAACCTCTTCCTGACGGAAGTATCGGTCCAGGAATTACAAATGTCG TTGGTGGCCC 36 ∼18 Bead RNA polymerase transcription Valero et al. [9 ] ATCCAGAGTGACGCAGCAATTTACCGATGGCTTGTTTGTAATGTAGGGTTCCGTCGGATTGGACACGGTGGCTTAGT 27 N protein RNA UGUCGUUCGCUGUCUUGCUACGUUACGUUACACGGUUGG — 1.65 ± 0.41 — — Parashar et al. [3 ] ACE2 ssDNA ATAGTCCCTGGCGTGCTTGACAGCAACACGAACACTGAACGTTCTTAACAAGCCTGGCAGAGCAGGTACGGTGTCA 40 33 Bead Denaturation and rapid cooling Villa et al. [10 ] ATAGTCCCTGGCGTGCTTCCGCGAGAGTTCGACATTCCCGAAAGTACGACGAAAGTCCAGAGCAGGTACGGTGTCA 47