Interdisciplinary Perspectives on Infectious Diseases / 2023 / Article / Tab 2 / Review Article
Aptamer-Based Strategies to Address Challenges in COVID-19 Diagnosis and Treatments Table 2 List of high-affinity ssDNA and RNA aptamers targeting N protein or RBD of the S protein isolated using different SELEX protocols as diagnostic agents for COVID-19.
Target Types Aptamer sequence (5′-3′) Randomization region length (bp) K D (nM)Partitioning method Selection pool regeneration method References N Protein ssDNA GCAATGGTACGGTACTTCCGGATGCGGAAACTGGCTAATTGGTGAGGCTGGGGCGGTCGTGCAGCAAAAGTGCACGCTACTTTGCTAA 45 — — — Chen et al. [2 ] N Protein ssDNA GCTGGATGTCGCTTACGACAATATTCCTTAGGGGCACCGCTACATTGACACATCCAGC 36 0.49 ± 0.05 — — Zhang et al. [5 ] GCTGGATGTCACCGGATTGTCGGACATCGGATTGTCTGAGTCATATGACACATCCAGC 0.70 ± 0.06 GCTGGATGTTGACCTTTACAGATCGGATTCTGTGGGGCGTTAAACTGACACATCCAGC 2.74 ± 0.08 GCTGGATGTTCATGCTGGCAAAATTCCTTAGGGGCACCGTTACTTTGACACATCCAGC 4.38 ± 0.06 SRBD ssDNA CAGCACCGACCTTGTGCTTTGGGAGTGCTGGTCCAAGGGCGTTAATGGACA 40 5.8 Bead Magnetic separation using streptavidin-coated bead Song et al. [4 ] ATCCAGAGTGACGCAGCATTTCATCGGGTCCAAAAGGGGCTGCTCGGGATTGCGGATATGGACACGT 19.9