Research Article

Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19

Table 3

Enriched data from WikiPathway 2021.

Term-valueAdjusted -valueGenes

Type I interferon induction and signaling during SARS-CoV-2 infection WP48682,88E − 084,00E − 06TBK1; OAS1; IRF3; STAT1; OAS2; STAT2; IRF7; TYK2; JAK1; IFNAR1
Immune response to tuberculosis WP41979,67E − 086,72E − 05OAS1; STAT1; STAT2; MX1; TYK2; IFIT1; IFIT3; JAK1; IFNAR1
Host-pathogen interaction of human coronaviruses-interferon induction WP48804,54E − 062,10E − 05TBK1; OAS1; IRF3; STAT1; OAS2; STAT2; TYK2; JAK1; IFNAR1
SARS-CoV-2 innate immunity evasion and cell-specific immune response WP50394,29E − 021,49E + 00IL6; TBK1; IRF3; STAT1; STAT2; MX1; IRF7; JAK1; IFNAR1
Hepatitis B infection WP46668,24E − 022,29E + 01IL6; TBK1; IRF3; STAT1; STAT2; STAT3; IRF7; TYK2; JAK1; IFNAR1
SARS coronavirus and innate immunity WP49127,92E − 031,84E + 01TBK1; IRF3; STAT1; STAT2; TYK2; JAK1; IFNAR1
Non-genomic actions of 1,25 dihydroxyvitamin D3 WP43412,04E + 014,06E + 02IL6; RSAD2; STAT1; OAS2; STAT2; ISG15; TYK2; JAK1
IL-10 anti-inflammatory signaling pathway WP44954,59E + 027,97E + 03IL6; STAT1; STAT2; STAT3; JAK1
Type II interferon signaling (IFNG) WP6199,95E + 021,54E + 05OAS1; STAT1; STAT2; IFI6; ISG15; JAK1
Interferon type I signaling pathways WP5851,09E + 051,52E + 06STAT1; STAT2; STAT3; TYK2; JAK1; IFNAR1
Type III interferon signaling WP21131,52E + 061,92E + 06STAT1; STAT2; TYK2; JAK1
Overview of interferon-mediated signaling pathway WP45582,48E + 052,88E + 06STAT1; STAT2; TYK2; JAK1; IFNAR1
IL-6 signaling pathway WP3645,47E + 055,84E + 07IL6; STAT1; STAT3; TYK2; JAK1
Toll-like receptor signaling pathway WP755,88E + 055,84E + 07IL6; TBK1; IRF3; STAT1; IRF7; IFNAR1
Regulation of toll-like receptor signaling pathway WP14493,62E + 073,35E + 07IL6; TBK1; IRF3; STAT1; IRF7; IFNAR1
Cytosolic DNA-sensing pathway WP46559,61E + 058,35E + 07IL6; TBK1; IRF3; IRF7; ISG15
TLR4 signaling and tolerance WP38511,47E + 081,20E + 09IL6; TBK1; IRF3; IRF7
Interleukin-11 signaling pathway WP23329,62E + 077,43E + 08STAT1; STAT3; TYK2; JAK1
Thymic stromal lymphoPoietin (TSLP) signaling pathway WP22031,26E + 099,23E + 08IL6; STAT1; STAT3; JAK1
IL-4 signaling pathway WP3952,23E + 091,55E + 10STAT1; STAT3; TYK2; JAK1