Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19

Table 2

GO terms associated with cytokines significant to COVID-19 cytokine storm.

GO type	GO term	Exist in the resulting cluster
Molecular function	1 Cytokine activity	Yes
	2 Growth factor activity	Yes
Cellular component	1 Extracellular space	Yes
	2 Extracellular region	Yes
Biological process	1 Immune response	No
	2 Cytokine-mediated signaling pathway	Yes
	3 Signal transduction	No
	4 Cellular response to lipopolysaccharide	Yes
	5 Inflammatory response	Yes
	6 Positive regulation of cell proliferation	No
	7 Positive regulation of transcription by RNA polymerase II	No
	8 Humoral immune response	Yes
	9 Positive regulation of gene expression	Yes
	10 Positive regulation of tyrosine phosphorylation of STAT protein	Yes
	11 Positive regulation of DNA-binding transcription factor activity	Yes
	12 Cell-cell signaling	No
	13 MAPK cascade	Yes
	14 Negative regulation of the apoptotic process	Yes