Review Article
Mutations Associated with Rifampicin Resistance in Mycobacterium tuberculosis Isolates from Moroccan Patients: Systematic Review
Table 3
Global frequency of mutations identified in the rpoB gene promoter of RIFR of MTB isolates.
| | Position | 511 | 513 | 516 | 518 | 520 | 522 | 526 | 527 | 531 | Dual mutation | Unknown mutation | | Type of mutation | CTG > CCG | CAA > CCA | GAA > CTA | CAA > CTA | GAC > GTC | GAC > TAC | GAC > CAC | D AAC | D CCG | TCG > TTG | CAC > TAC | CAC > CTC | CAC > TGC | CAC > CGC | CAC > AGC | CAC > AAC | CAC > GAC | AAG > CAG | TCG > TTG | TCG > TGG |
| | Amino acid change | Leu/Pro | Glu/Pro | Glu/Leu | Glu/Leu | Asp/Val | Asp/Tyr | Asp/His | — | — | Ser/Leu | His/Tyr | His/Leu | His/Cys | His/Arg | His/Ser | His/Asn | His/Asp | Lys/Glu | Ser/Leu | Ser/Trp | — | — | | Oudghiri et al. 2018 [26], n = 90 | — | 1 | — | 1 | 3 | 2 | 3 | — | — | — | — | — | — | 3 | 4 | — | — | — | 62 | 5 | — | 6 | | Karimi et al. 2018 [27], n = 38 | — | — | — | — | 4 | — | — | — | — | — | — | — | — | — | — | — | 8 | — | 23 | — | — | 3 | | Ennassiri et al. 2017 [28], n = 116 | — | — | — | — | 9 | — | — | — | — | — | 2 | — | — | — | — | — | 6 | — | 78 | — | 3 | 18 | | Bentaleb et al. 2017 [29], n = 45 | — | — | — | — | — | — | — | — | — | — | 2 | 1 | 3 | — | — | — | — | — | 32 | 2 | — | 5 | | Chaoui et al. 2014 [24], n = 154 | 1 | — | — | — | 9 | 4 | — | — | — | 2 | 4 | 1 | 1 | — | — | 1 | — | — | 109 | 8 | — | 14 | | Zakham et al. 2013 [25], n = 29 | — | 1 | 1 | — | 2 | 2 | 1 | 2 | 1 | — | — | — | — | 1 | 1 | — | — | 1 | 12 | 1 | — | 3 | | Total number (n = 472) | 1 | 2 | 1 | 1 | 27 | 8 | 4 | 2 | 1 | 2 | 8 | 2 | 4 | 4 | 5 | 1 | 14 | 1 | 316 | 16 | 3 | 49 | | Cumulative frequencies % | 0.21 | 0.85 | 8.26 | 0.42 | 0.21 | 0.42 | 8.05 | 0.21 | 70.33 | 0.64 | 10.38 |
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Dual mutation in position 516 & 531. D Deletion. |
