Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice
Figure 3
Histological lesions and immunohistochemical detection of viral antigen in heart, intestine, kidneys, and spleen of chicken infected with HPAI A(H5N8) virus; viral antigen staining in red. Note: (a) the lymphohistiocytic myocarditis. Bar = 20 μm. (b) Viral antigen in myocytes. Bar = 20 μm. (c) Intensive mononuclear infiltration of the small intestine; desquamation of epithelium. Bar = 20 μm. (d) Viral antigen in epithelial cells. Bar = 20 μm. E Venous and capillary hyperemia of kidney. Bar = 20 μm. (f) Viral antigens in kidney tubular epithelial cells. Magnification x40. (g) Local area of necrosis in spleen. Bar = 20 μm. (h) Viral antigen in spleen macrophages. Bar = 20 μm. HE: hematoxylin-and-eosin staining; IHC: immunohistochemical staining.