Assessing the Impact of Isoniazid Preventive Therapy (IPT) on Tuberculosis Incidence and Predictors of Tuberculosis among Adult Patients Enrolled on ART in Nekemte Town, Western Ethiopia: A Retrospective Cohort Study
Table 5
Effect of IPT on reduction of tuberculosis incidence among cohorts of PLWHA at Nekemte referral hospital and Nekemte Health center followed from September 2009-September 2012.
IPT adjusted covariates
Unadjusted hazard 95%CI
p-value
Adjusted Hazard 95 %CI
p-value
Significant reduction in TB (%)
p-value for interaction
IPT
0.397(0.203- 0.774)
0.007
0.449(0.219-0.920)¥
0.029
55¥
IPT∗ Cotrimoxazole
0.402(0.206-0.784)
0.007
60
0.219
IPT∗ WHO stage
0.382(0.196-0.745)
0.005
62
0.48
IPT∗ CD4 count
0.348(0.176-0.685)
0.002
65
0.64
IPT∗ Functional status
0.386(0.198-0.754)
0.005
61
0.08
IPT∗ BMI
0.403(0.206-0.788)
0.012
60
0.072
IPT∗ Weight
0.426(0.218-0.831)
0.008
57
0.74
IPT∗ Sex
0.399(0.204-0.778)
0.007
40
0.85
IPT∗ opportunistic infection
0.396(0.203-0.773)
0.007
60
0.61
IPT∗ age
0.403(0.206-0.788)
0.008
60
0.065
IPT∗ previous TB
0.401(0.205-0.785)
0.008
60
0.588
∗IPT adjusted for each covariate. ¥Overall effect of IPT adjusted for all covariates.
