Assessing the Impact of Isoniazid Preventive Therapy (IPT) on Tuberculosis Incidence and Predictors of Tuberculosis among Adult Patients Enrolled on ART in Nekemte Town, Western Ethiopia: A Retrospective Cohort Study
Table 4
Predictors of tuberculosis risk, multivariate analysis by Cox proportional hazard model of PLWHA at Nekemte referral hospital and Nekemte Health center followed from September 2009-September 2012.
Variables (n=600)
Category
Unadjusted HR(95%CI
P-value
Adjusted HR(95%CI
P-value
Age
<=30
Referent
Referent
31-40
0.47(0.23-0.95)
0.035∗
0.47(0.23-1.05)
0.06#
41-50
1.05(0.46-2.38)
0.92
1.05(0.46-2.38)
0.072#
>50
2.9(1.13-7.5)
0.027∗
2.9(1.13-7.5)
0.08#
CD4 Count
>500
Referent
351-500
1.25(0.314-5.16)
0.749
1.25(0.89 -5.16)
0.68#
201-350
4.9(1.6-14.6)
0.005∗
4.9(1.6-14.6)
0.007
<=200
17.5 (6.15-50)
<0.001∗
17.5 (6.15-50)
<0.001
Sex
Male
Referent
Female
1.095(0.83-
0.525
BMI
>=18.5
Referent
referent
<18.5
3.13(1.77-5.53)
<0.001∗
3.13(1.77-5.53)
0.042
Weight
>50
Referent
Referent
<=50
1.72(1.28 -2.28)
0.001∗
1.72(1.28 -2.28)
0.041
WHO Stage
I/II
Referent
Referent
III/IV
3.22(0.96-4.56)
0.08∗
3.22(1.96-4.56)
0.037
Functional Status
Working
Referent
Referent
Ambulatory/Bedridden
3.38(1.9-5.96)
<0.001∗
3.38(1.9-5.96)
0.022
Cotrimoxazole Treatment
Yes
Referent
Referent
No
4.21(2.42-7.4)
<0.001∗
4.21(2.42-7.4)
<0.001
Previous TB
No
Referent
Yes
1.43(0.56-3.58)
0.45
Opportunistic Infection
No
Referent
Referent
Yes
1.02(0.51-2.02)
0.06∗
1.02(0.51-2.02)
0.061#
Cohort Group
Yes
Referent
Referent
No
2.5(1.3-4.9)
.007∗
2.5(1.3-4.9)
0.03
∗All candidate variables for multivariate analysis. #Lost statistical significance in multivariate analysis.
