Clinical Study
Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations
Table 1
Characteristics of study subjects.
| Characteristics | Nomogram () | Traditional () | P value |
| Age (yrs)a | 58 ± 18 | 61 ± 17 | 0.040 | Actual body weight (kg)a | 83.6 ± 18.7 | 83.9 ± 17.4 | 0.873 | Ideal body weight (kg)a | 63.5 ± 10.6 | 65.5 ± 11.6 | 0.051 | Height (in)a | 66.8 ± 3.9 | 67.5 ± 4.3 | 0.051 | Initial SCr (mg/dL)a | 0.96 ± 0.31 | 1.0 ± 0.38 | 0.143 | Change in SCr (%)a | 14 ± 11.6 | 15 ± 11.5 | 0.389 | Intensive care unit admission: n (%) | 40 (18) | 57 (23) | 0.271 | Gender: n (% Females) | 107 (48) | 105 (42) | 0.168 | Patients stratified by creatinine clearance: n (%) | | | | ≥100 mL/min | 79 (35.7) | 59 (23.4) | | 80–99 mL/min | 27 (12.2) | 46 (18.3) | | 60–79 mL/min | 53 (24.0) | 59 (23.4) | | 40–59 mL/min | 42 (19.0) | 51 (20.2) | | 20–39 mL/min | 20 (9.0) | 37 (14.7) | | ≤19 mL/min | 0 | 0 | | Patients stratified by diagnosis: n (%) | | | | Pneumonia | 66 (29.9) | 76 (30.2) | | Cellulitis | 68 (30.8) | 72 (28.6) | | Bacteremia | 32 (14.5) | 32 (12.7) | | Osteomyelitis | 11 (5.0) | 13 (5.2) | | Abscess | 15 (6.8) | 11 (4.4) | | Empiric | 10 (4.5) | 16 (6.3) | | Urinary tract infection | 2 (0.9) | 9 (3.6) | | Respiratory failure | 3 (1.4) | 6 (2.4) | | Miscellaneous: endocarditis, meningitis, febrile neutropenia, diverticulitis, and wounds | 14 (6.3) | 17 (6.7) | |
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aMean ± standard deviation. SCr: serum creatinine.
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