Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Figure 6
Trypanosoma cruzi epimastigotes treated with ketoconazole, an inhibitor of the C-demetilase (a)-(b), and L. amazonensis promastigotes treated with E5700, an inhibitor of the squalene synthase (c) showing an intense mitochondrial swelling (a)-(b) and alterations in the kinetoplast structure ((c), arrowhead). K, kinetoplast; M, mitochondrion. (a)-(b) Images are reproduced with permission from [74] American Society for Microbiology. Bars, m.
