TY - JOUR A2 - Aihara, Ken-ichi AU - Yamakuchi, Munekazu PY - 2012 DA - 2012/09/26 TI - MicroRNAs in Vascular Biology SP - 794898 VL - 2012 AB - Vascular inflammation is an important component of the pathophysiology of cardiovascular diseases, such as hypertension, atherosclerosis, and aneurysms. All vascular cells, including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and infiltrating cells, such as macrophages, orchestrate a series of pathological events. Despite dramatic improvements in the treatment of atherosclerosis, the molecular basis of vascular inflammation is not well understood. In the last decade, microRNAs (miRNAs) have been revealed as novel regulators of vascular inflammation. Each miRNAs suppresses a set of genes, forming complex regulatory network. This paper provides an overview of current advances that have been made in revealing the roles of miRNAs during vascular inflammation. Recent studies show that miRNAs not only exist inside cells but also circulate in blood. These circulating miRNAs are useful biomarkers for diagnosis of cardiovascular diseases. Furthermore, recent studies demonstrate that circulating miRNAs are delivered into certain recipient cells and act as messengers. These studies suggest that miRNAs provide new therapeutic opportunities. SN - 2090-2824 UR - https://doi.org/10.1155/2012/794898 DO - 10.1155/2012/794898 JF - International Journal of Vascular Medicine PB - Hindawi Publishing Corporation KW - ER -