Caffeine's Vascular Mechanisms of Action

<table>Indirect effects of caffeine on VSMC.  Caffeine acts on the endothelial cell increasing cytoplasmic <svg height="16.1" id="M7" style="vertical-align:-0.20473pt" version="1.1" viewbox="0 0 32.362499 16.1" width="32.362499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> which will form the calcium-calmodulin complex which activates the nitric oxide synthase enzyme to produce nitric oxide.  This diffuses to the VSMC.</table>

International Journal of Vascular Medicine

Caffeine's Vascular Mechanisms of Action

Figure 4