Concomitant Radiotherapy and Chemotherapy for High-Risk Nonmelanoma Skin Carcinomas of the Head and Neck

Table 3

Univariate and multivariate hazard ratios of relapse free survival.

Univariate			Multivariate
Factor	HR (95% CI)	P value	Factor	HR (95% CI)	P value
Basal cell histology	0.61 (0.3–1.3)	0.40	Bone invasion	9.43 (2.8–32)	<0.01
Well-differentiated	0.93 (0.4–2.2)	0.93	Radiation alone	2.72 (7.9–9.3)	0.11
T4 disease	0.83 (0.4–1.7)	0.72	Nodal disease	2.60 (1.3–5.1)	0.01
Unresectable	0.84	0.76
Local invasion	2.25 (1.0–4.8)	0.17
Bone	5.25 (2.5–11.1)	<0.01
Nerves	1.91 (0.9–4.1)	0.27
Soft tissue	1.21 (0.6–2.5)	0.73
Nodal disease	1.35 (0.8–2.2)	0.19
Positive margins	1.68 (0.8–3.5)	0.34
Recurrence	1.01 (0.5–2.1)	0.99
Radiation alone	0.71 (0.3–1.5)	0.53
Radiation break	2.04 (0.9–4.6)	0.27
Chemotherapy missed*	3.52 (1.4–8.8)	0.13

*Applicable to chemoradiotherapy patients. HR, hazard ratio; CI, confidence interval.