Simple Atomic Absorption Spectroscopic and Spectrophotometric Methods for Determination of Pioglitazone Hydrochloride and Carvedilol in Pharmaceutical Dosage Forms
Table 6
Results of the analysis for determination of PGZ-HCl and CRV (authentic) using Method B.
Parameters
PGZ-HCl*
CRV*
Fast green FCF method
Orange G method
Fast green FCF method
Orange G method
Taken gmL−1
Found gmL−1
Recovery %
Taken gmL−1
Found gmL−1
Recovery %
Taken gmL−1
Found gmL−1
Recovery %
Taken gmL−1
Found gmL−1
Recovery %
0.5
0.51
101.18
10
10.02
100.21
0.5
0.50
99.66
5
5.01
100.19
1
0.99
99.43
20
20.02
100.10
1
1.00
99.50
10
10.01
100.10
1.5
1.51
100.57
30
29.81
99.37
1.5
1.50
100.07
20
19.86
99.32
2
1.98
99.07
40
39.95
99.88
2
2.01
100.36
25
25.25
101.01
2.5
2.51
100.24
50
50.44
100.88
2.5
2.51
100.41
30
30.11
100.36
3
3.00
99.98
60
60.23
100.38
3
2.99
99.60
40
40.01
100.02
4
4.00
100.05
70
69.74
99.63
45
45.06
100.13
Mean
100.08
100.07
99.93
100.16
±SD
0.70
0.50
0.40
0.50
±RSD
0.70
0.50
0.40
0.50
±SE
0.26
0.19
0.16
0.19
Variance
0.49
0.25
0.16
0.25
Slope
0.1945
0.0143
0.3201
0.0206
LOD gmL−1
0.13
0.23
0.078
0.16
LOQ gmL−1
0.39
0.7
0.24
0.49
Sandell’s sensitivity gcm−2
0.0036
0.078
0.0032
0.046
Apparent Molar absorptivity LMol−1cm−1
Average of three different trials of determination.