Simple Atomic Absorption Spectroscopic and Spectrophotometric Methods for Determination of Pioglitazone Hydrochloride and Carvedilol in Pharmaceutical Dosage Forms
Table 1
Characteristic parameters for the reaction of PGZ-HCl and CRV with bismuth tetraiodide via Method A*.
Parameters
PGZ-HCl
CRV
Procedure 1
Procedure 2
Procedure 1
Procedure 2
(nm)
223
490
223
490
Beer's law limits (g mL−1)
5–50
15–65
10–80
16–72
Vol. and conc. of bismuth subnitrate of M
0.3 mL
0.3 mL
0.4 mL
0.4 mL
Vol. and conc. of potassium iodide of 0.5 M
0.5 mL
0.5 mL
0.7 mL
0.7 mL
Extracting solvent
Methylene chloride
Methylene chloride
Methylene chloride
Methylene chloride
Regression equation**
Slope ()
2.7642
0.0143
3.7383
0.0136
Intercept ()
102.52
0.0177
55.097
−0.0932
Correlation coefficient ()
0.9999
0.9999
0.9999
0.9999
Molar ratio
1 : 1
1 : 1
1 : 1
1 : 1
, where is the concentration of drug in gmL−1, is the absorbance, is the intercept, and is the slope
