Development and Validation of a Discriminating In Vitro Dissolution Method for Oral Formulations Containing Satranidazole

Table 1

pH dependent solubility of Satranidazole in different buffer solutions.

pH	Solubility (mg/mL)*	Sink condition
1.2 (0.1 N HCl)	1.5125	4.5375
2.1 (0.01 N HCl)	1.1985	3.5955
4.5 (acetate buffer)	0.9813	2.9439
6.8 (phosphate buffer)	0.8251	2.4753
7.4 (phosphate buffer)	0.9825	2.9475
Distilled water	0.8133	2.4399

∗Mean of 3 determinations.