New Kinetic Spectrophotometric Method for Determination of Fexofenadine Hydrochloride in Pharmaceutical Formulations

Table 4

Determination of FEX in different pharmaceutical formulations by the proposed and official methods.

Formulation	Label claim	% Found^a  ± SD
		Proposed methods		Official method [31]
		Initial rate	Fixed time
Allergy stop^b	60 mg/Cap	100.75 ± 0.19	101.04 ± 0.21	100.79 ± 0.13
		t = 1.99	t = 2.17	t = 1.32
		F = 2.14	F = 2.61
	120 mg/Tab	101.06 ± 0.20	100.12 ± 0.18	101.05 ± 0.15
		t = 2.05	t = 1.75	t = 1.28
		F = 1.78	F = 1.44
	180 mg/Tab	99.98 ± 0.18	100.60 ± 0.20	99.78 ± 0.14
		t = 1.68	t = 1.36	t = 1.79
		F = 1.65	F = 2.04
Fexofenadine^c	60 mg/Cap	100.27 ± 0.15	101.00 ± 0.13	100.84 ± 0.11
		t = 1.99	t = 1.00	t = 1.88
		F = 1.86	F = 1.41
Fenadin^d	120 mg/Tab	101.96 ± 0.13	100.26 ± 0.14	99.69 ± 0.12
		t = 1.67	t = 2.06	t = 1.24
		F = 1.17	F = 1.52
	180 mg/Tab	100.95 ± 0.20	101.08 ± 0.23	100.52 ± 0.18
		t = 1.70	t = 1.12	t = 1.81
		F = 1.23	F = 1.63

aFive independent analyses. At 95% confidence level t-value is 2.776 and F-value is 6.26.
^bSupplied by Pharmasyr, Syria; ^csupplied by Ibn-Alhaytham, Syria; ^dsupplied by BPI, Syria.