Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys

Figure 1

Joint swelling score in collagen-induced arthritis monkeys. The swelling levels of DIP, PIP, and MP joints in 5 digits of the forelimbs and hindlimbs as well as wrist, ankle, elbow, and knee joints in individual animals were evaluated in a blinded manner in accordance with the following criteria: score 0: no abnormality; score 1: swelling not visible but can be determined by touch; score 2: swelling slightly visible and can be confirmed by touch; score 3: swelling clearly visible; score 4: rigidity of the joints. The maximum score is 256 (total 64 joints/body and arthritic scores 0–4). Data are expressed as median (quantile 3-1); control (n=8), ONO-5334 (n=9), methotrexate (n=8), and combination (n=9).