Cardiac Function and Diastolic Dysfunction in Behcet’s Disease: A Systematic Review and Meta-Analysis

Table 2

Meta-analysis outcomes (random-effects model).

Variables	Mean difference (95% CI)			, %
Left atrial dimension, cm ()	0.08 (0.03, 0.12)	0.0008	11.13	0	0.00
Left ventricular mass index, gm/m^2 ()	3.53 (−1.08, 8.14)	0.13	0.11	0	0.00
Isovolumetric relaxation time, msec ()	7.29 (4.86, 9.72)	<0.0001	18.48	35	6.64
Transmitral wave velocity, meters/second ()	0.03 (−0.01, 0.08)	0.18	37.21	79	0.00
Transmitral wave velocity, meters/second ()	−0.03 (−0.06, 0.00)	0.07	15.04	47	0.00
ratio ()	−0.24 (−0.48, 0.00)	0.05	36.50	89	0.06
Mitral deceleration time, msec ()	14.20 (7.67, 20.73)	<0.0001	32.96	34	82.96
Left ventricular ejection fraction, % ()	−1.08 (−1.58, −0.58)	<0.0001	15.14	0	0.00
Posterior wall, cm ()	0.00 (−0.03, 0.03)	0.81	25.01	64	0.00
Left ventricular end systolic dimension, cm ()	0.03 (−0.04, 0.10)	0.37	18.03	45	0.01
Left ventricular end diastolic dimension, cm ()	−0.02 (−0.08, 0.04)	0.46	16.31	26	0.00
BSA, m^2 ()		0.12
LV MPI ()	0.04 (−0.07, 0.16)	0.48	47.96	96	0.01
Aorta, cm ()	0.16 (0.03, 0.29)	0.02	27.88	78	0.02
Aortic distensibility ()	−1.23 (−3.06, 0.60)	0.19	27.69	96	1.69
Systolic blood pressure, mmHg ()	1.69 (0.16, 3.22)	0.03	14.59	11	0.92
Diastolic blood pressure, mmHg ()	1.34 (0.29, 2.39)	0.01	12.69	5	0.20
Heart rate ()	0.68 (−0.76, 2.13)	0.35	29.14	59	2.85
Males, % ()	0.96 (0.87, 1.06)	0.39	4.16	0	0.00
Age, mean years ()	−0.40 (−1.32, 0.53)	0.40	17.98	5	0.22
BMI, kg/m^2 ()	−0.27 (−0.82, 0.27)	0.32	16.32	39	0.29
Diabetes mellitus ()	1.31 (0.42, 4.05)	0.64	0.17	0	0.00
Hypertension ()	0.92 (0.52, 1.65)	0.79	0.30	0	0.00
Hyperlipidemia ()	1.15 (0.50, 2.64)	0.74	0.62	0	0.00
Smoking ()	0.97 (0.83, 1.15)	0.76	5.04	0	0.00
Low density lipoprotein, mg/dL ()	−0.72 (−7.48, 6.05)	0.84	22.89	74	54.06
HDL, mg/dL ()	−0.91 (−3.38, 1.56)	0.47	13.30	55	5.44
Triglycerides, mg/dL ()	−1.35 (−10.86, 8.16)	0.78	11.79	49	72.83
Total cholesterol, mg/dL ()	−0.65 (−7.16, 5.85)	0.84	13.91	42	36.40
HS-CRP, mg/dL ()	7.79 (1.89, 13.68)	0.01	10.47	71	24.27

Risk ratio.
Cochran’s -statistic for heterogeneity.
index for degree of heterogeneity.
Tau-squared measure of heterogeneity.