HBV Reactivation in Patients Treated with Antitumor Necrosis Factor-Alpha (TNF-α) Agents for Rheumatic and Dermatologic Conditions: A Systematic Review and Meta-Analysis

Table 6

Meta-analysis on HBV reactivation among patients with no antiviral prophylaxis.

First author, year	Number of patients	HBV reactivation (𝑛)	HBV reactivation (%)	CI 95%	Weight (%)
All  patients
Caporali et al., 2010 [11]	67	0	0.0	0.0–5.4	11.2
Cassano et al., 2011 [12]	62	0	0.0	0.0–5.8	11.0
Charpin et al., 2009 [13]	21	0	0.0	0.0–15.5	8.0
Kim et al., 2010 [14]	88	14	15.9	9.7–24.9	11.7
Lan et al., 2011 [15]	78	6	7.7	3.6–15.8	11.5
Mori, 2011 [16]	32	1	3.1	0.5–15.7	9.3
Ryu et al., 2012 [17]	29	2	6.9	1.9–22.0	9.0
Tamori et al., 2011 [18]	42	0	0.0	0.0–8.4	10.1
Urata et al., 2011 [19]	52	5	9.6	4.2–20.6	7.7
Vassilopoulos et al., 2010 [20]	19	0	0.0	0.0–16.8	10.6
Pooled estimate			4.0	1.2–8.3	100.0

Heterogeneity chi-squared = 36.92 (d.f. = 9) 𝑃 = 0.000.
𝐼-squared (variation in ES attributable to heterogeneity) = 75.6%.