HBV Reactivation in Patients Treated with Antitumor Necrosis Factor-Alpha (TNF-α) Agents for Rheumatic and Dermatologic Conditions: A Systematic Review and Meta-Analysis

Table 5

Meta-analysis on HBV reactivation among patients treated with adalimumab.

First author, year	Number of patients	HBV reactivation (𝑛)	HBV reactivation (%)	CI 95%	Weight (%)
All  patients
Caporali et al., 2010 [11]	19	0	0.0	0.0–16.8	35.0
Cassano et al., 2011 [12]	48	3	0.0	2.2–16.8	65.0
Pooled estimate			4.6	0.5–12.5	100.0

Heterogeneity chi-squared = 1.40 (d.f. = 1) 𝑃 = 0.236.
𝐼-squared (variation in ES attributable to heterogeneity) = 28.7%.