International Journal of Rheumatology / 2014 / Article / Tab 2 / Review Article
HBV Reactivation in Patients Treated with Antitumor Necrosis Factor-Alpha (TNF-α ) Agents for Rheumatic and Dermatologic Conditions: A Systematic Review and Meta-Analysis Table 2 Meta-analysis of the prevalence of HBV reactivation among patients treated with biologic agents.
(a) First author, year Number of patients HBV reactivation (
) HBV reactivation (%) CI 95% Weight (%) All patients Caporali et al., 2010 [11 ] 67 0 0.0 0.0–5.4 10.9 Cassano et al., 2011 [12 ] 62 0 0.0 0.0–5.8 10.7 Charpin et al., 2009 [13 ] 21 0 0.0 0.0–15.5 7.5 Kim et al., 2010 [14 ] 88 14 15.9 9.7–24.9 11.4 Lan et al., 2011 [15 ] 88 6 6.8 3.2–14.1 11.4 Mori, 2011 [16 ] 32 1 3.1 0.6–16.2 8.9 Ryu et al., 2012 [17 ] 49 3 6.1 2.1–16.5 10.1 Tamori et al., 2011 [18 ] 44 0 0.0 0.0–7.1 9.8 Urata et al., 2011 [19 ] 52 5 9.6 4.2–20.6 10.3
Vassilopoulos et al., 2010 [20 ] 33 1 3.0 0.5–15.3 9.0 Pooled estimate 4.2 1.4 –8.2 100.0
Heterogeneity chi-squared = 35.55 (d.f. = 9)
= 0.000.
-squared (variation in ES attributable to heterogeneity) = 74.7%. (b) First author, year Number of patients HBV reactivation (
) HBV reactivation (%) CI 95% Weight (%) Patients with overt chronic HBV infection Lan et al., 2011 [15 ] 18 5 27.8 12.5–50.9 45.5 Ryu et al., 2012 [17 ] 49 3 6.1 2.1–16.5 54.5 Pooled estimate 15.4 1.2–41.2 100.0
Heterogeneity chi-squared = 4.98 (d.f. = 1)
= 0.026.
-squared (variation in ES attributable to heterogeneity) = 79.9%. (c) First author, year Number of patients HBV reactivation (
) HBV reactivation (%) CI 95% Weight (%) Patients with occult HBV infection Caporali et al., 2010 [11 ] 67 0 0.0 0.0–5.4 12.3 Cassano et al., 2011 [12 ] 62 0 0.0 0.0–5.8 12.1 Charpin et al., 2009 [13 ] 21 0 0.0 0.0–15.5 8.9 Kim et al., 2010 [14 ] 88 14 15.9 9.7–24.9 12.8 Lan et al., 2011 [15 ] 70 1 1.4 0.2–7.7 12.4 Mori, 2011 [16 ] 31 1 3.2 0.6–16.2 10.2 Tamori et al., 2011 [18 ] 42 0 0.0 0.0–8.4 11.3 Urata et al., 2011 [19 ] 52 5 9.6 5.4–23.0 11.7
Vassilopoulos et al., 2010 [20 ] 19 0 0.0 0.0–16.8 8.6 Pooled estimate 3.0 0.6 –7.2 100.0
Heterogeneity chi-squared = 34.94 (d.f. = 8)
= 0.000.
-squared (variation in ES attributable to heterogeneity) = 77.1%.