The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis

Table 1

Systemic sclerosis-associated autoantibodies, potentially pathogenic antibodies which have been described in a proportion of patients with systemic sclerosis. Reviewed in [41]. ECM: extracellular matrix.

Autoantibody	In vitro activity
Antiendothelial cell	Endothelial cell apoptosis
Antifibrillin 1	Fibroblast activation, increased ECM production
Antimatrix metalloproteinase	Prevent degradation of the ECM
Anti-PDGFR	Induce collagen 1 production Convert fibroblasts to myofibroblasts
Antifibroblast	Increased expression of ICAM and IL-6
Anti-HSP47	Not known