Vascular Changes in Bleomycin-Induced Scleroderma

Figure 1

(a) Sclerotic skin induced by bleomycin injection. (b) Close-up view of the vascular lesions showing thickened wall. (c) Elastica van Gieson (EVG) stain showing proliferation of arterial intima. (d) α-SMA stain showing proliferation of vascular smooth muscle cells. (e)–(g) Vascular features of control mice treated with PBS were shown (e; H-E, f; EVG, g; α-SMA stain).