Controlled Release Bilayer Floating Effervescent and Noneffervescent Tablets Containing Levofloxacin and Famotidine

Table 5

Release kinetics of levofloxacin and famotidine from bilayer floating tablets.

Drugs	Code	Zero order	First order	Higuchi model	Korsmeyer-Peppas model				BFM
						(min^-1)		Release mechanism
Levofloxacin layer (FL)	FL1	0.682	0.963	0.971	0.969	21.6	0.46	Non-Fickian	HUM
	FL2	0.677	0.928	0.978	0.981	22.6	0.45	Non-Fickian	KPM
	FL3	0.199	0.878	0.850	0.959	34.9	0.32	Fickian	KPM
	FL4	0.815	0.934	0.976	0.978	14.5	0.54	Non-Fickian	KPM
	FL5	1.000	0.974	0.968	0.971	14.9	0.57	Non-Fickian	ZO
Famotidine layer (FM)	FM1	0.810	0.956	0.990	0.991	17.1	0.53	Non-Fickian	KPM
	FM2	0.681	0.972	0.977	0.979	22.9	0.46	Non-Fickian	KPM
	FM3	0.882	0.972	0.971	0.983	13.9	0.60	Non-Fickian	KPM
	FM4	0.970	0.910	0.791	0.981	1.31	1.29	Non-Fickian	KPM
	FM5	0.855	0.970	0.982	0.989	14.1	0.57	Non-Fickian	KPM

Note: best fitting model: BFM; zero order: ZO; Higuchi model: HUM; Korsmeyer-Peppas model: KPM.