Electrospun Fibers: Versatile Approaches for Controlled Release Applications
Table 1
Summarized information about different types of electrospinning.
Electrospinning type
Suggested molecules for delivery
Advantages
Limitations
Blend electrospinning
Small molecules
The simplest method of electrospinning
Harsh process for sensitive molecules
Sequential electrospinning
Small molecules
Relatively simple method, multiphasic delivery
Harsh process for sensitive molecules independent non-protected layers
Coaxial/multiaxial electrospinning
Wide range of drugs, such as small molecules, proteins, and RNA
Possibility to form core–shell nanofibers from miscible and immiscible polymers high loading capacity less harsh process multiphasic delivery with complex release profiles
Optimization of multineedle methods low production rate compatibility of core and shell fluids
Emulsion electrospinning
Wide range of drugs, such as small molecules, proteins, and RNA
Single nozzle formation of core–shell structure
Choosing polymers with sufficient interfacial tension needed care for preparation of emulsion