Application of Eudragit RS 30D as a Potential Drug Release Retardant of Acetaminophen and Caffeine for Prolonged Duration of Comfort

Table 4

Release kinetics of acetaminophen and caffeine from formulation EF1-EF3.

		Acetaminophen			Caffeine
pH 1.2		EF1	EF2	EF3	EF1	EF2	EF3
Zero-order		10.686	9.742	9.546	10.396	8.877	10.350
		0.536	0.804	0.815	0.830	0.820	0.693
Hixson-Crowell		0.072	0.055	0.052	0.060	0.045	0.065
		0.859	0.949	0.938	0.917	0.878	0.929
Higuchi		30.765	27.581	26.936	29.234	24.966	29.561
		0.962	0.990	0.963	0.943	0.939	0.991
Korsmeyer-Peppas		35.852	25.174	23.403	24.145	21.307	30.552
		0.9766	0.9934	0.9699	0.955	0.948	0.992
pH 4.5		EF1	EF2	EF3	EF1	EF2	EF3
Zero-order		9.514	9.728	0.1579	12.037	9.252	11.327
		0.858	0.808	0.125	0.1579	0.7402	0.5045
Hixson-Crowell		0.050	0.055	0.8663	0.125	0.050	0.092
		0.911	0.949	35.609	0.8663	0.8943	0.9497
Higuchi		26.672	27.530	0.802	35.609	26.298	32.770
		0.943	0.989	52.566	0.802	0.982	0.966
Korsmeyer-Peppas		21.179	24.965	0.973	52.566	25.955	38.312
		0.960	0.993	12.037	0.973	0.982	0.982
pH 6.8		EF1	EF2	EF3	EF1	EF2	EF3
Zero-order		9.028	9.010	8.789	11.489	9.688	11.739
		0.981	0.988	0.979	0.726	0.748	0.650
Hixson-Crowell		0.046	0.045	0.045	0.084	0.055	0.093
		0.916	0.942	0.951	0.992	0.921	0.997
Higuchi		25.275	25.068	24.752	32.739	27.555	33.677
		0.943	0.937	0.975	0.941	0.989	0.947
Korsmeyer-Peppas		19.586	17.158	20.829	30.548	26.961	34.276
		0.9626	0.9744	0.9853	0.943	0.989	0.947