Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering

Table 2

Summary of the growth factor, polymer used, and size of microspheres studies recently released.

Polymer	Growth factor	Formation technique	Microsphere size	Reference
PEG-PLGA diblock	BMP-2	w/o/w	37–67 μm	[48]
PLGA/PLGA-PEG-PLGA	BMP-2	w/o/w	67–127 μm	[61]
Gelatine cross-linked with genipin	BMP-2	w/o	undisclosed	[72]
Gelatine cross-linked with genipin	BMP-2	w/o	2–6 μm	[52]
PLGA	BMP-2	w/o/w	100–150 μm	[63]
PLGA	BMP-2	w/o/w	Average of 50 μm	[113]
PLGA	BMP-2	w/o/w	Undisclosed	[114]
PLGA	VEGF	w/o/w	Undisclosed	[115]
PLGA	VEGF	w/o/w	20–53 μm	[116]
PLGA	VEGF + FGF-2	w/o/w	undisclosed (fused microsphere bridge)	[108]
PLGA	VEGF + FGF-2	s/o/w	Undisclosed	[67]
Alginate	VEGF	w/o/w	300–400 μm	[47]
PEG-CAM-PEG	VEGF + BMP-2	s/o/w	5–30 μm	[117]
PLGA	VEGF, FGF-2,; VEGF + FGF-2	w/o/w	~20–100 μm	[65]
PLGA	PDGF	w/o/w	7–31 μm	[118] microsphere formation in [119]
PLGA	BMP-2 + TGFβ	Ultrasound o/w	Undisclosed (fused microsphere bridge)	[120]
PLGA	LTB4	w/o/w	5–10 μm	[107]
Hyaluronic acid	BMP-2	w/o/w	710 nm–1.7 μm	[121]
PLGA	BMP-2	w/o/w	120–470 μm	[122]
P(TMC-CL)2-PEG	BMP-6 + TGFβ3	Electrospraying o/w	~65-80 μm	[51]
Gelatine cross-linked with glutaraldehyde	VEGF + BMP-2	w/o	50–100 μm	[70]
Silk fibroin	BMP-2 BMP-9 or BMP-14	Nanoprecipitation	2.4–3 μm	[58]
PLLA	BMP-2	w/o	35–55 nm	[104]