Research Article

Total Chemical Synthesis of a Heterodimeric Interchain Bis-Lactam-Linked Peptide: Application to an Analogue of Human Insulin-Like Peptide 3

Table 1

Receptor binding affinities ( ) of INSL3 and analogues. Data for entry 2 taken from reference [32].

PeptideReceptor binding (n=)

Human INSL3 (6)
ΔA25/26 human INSL3 (3)
ΔA25/26 human INSL3
mono-lactam A24-B22
(3)
ΔA25/26 human INSL3
bis-lactam A11-B10, A24-B22
(3)