Review Article
Antimicrobial Lactoferrin Peptides: The Hidden Players in the Protective Function of a Multifunctional Protein
Table 1
Amino acid sequences of LF1-11 from lactoferrin from six species.
| | LF1-11 | Lactoferrampin | Lactoferricin |
| Sequence | GRRRSVQWCAV | WNLLRQAQEKFGKDKSP | KCFQWQRNMRKVRGPPVSCIKRDS | pI | 11.70 | 9.70 | 10.95 | Secondary structure in the intact lactoferrin [X-ray crystallography] | Loop followed by β-strand | Amphipathic helix with a C-terminal tail | N-terminal amphipathic helix connected to a β-strand with a loop. The structural assembly is held together with a disulphide bond. | Secondary structure when isolated [NMR] | Not known | N-terminal amphipathic alpha-helical conformation across the first 11 residues and random C-terminus | N-terminal amphipathic helix and a random coil |
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