Platelet-Rich Plasma Peptides: Key for Regeneration

Table 1

Peptidic growth factors present in platelet-rich plasma (PRP).

Name	Cytogenetic location	Biologic activities
Transforming growth factor, beta-I; TGFB1	19q13.2	Controls proliferation, differentiation, and other functions in many cell types
Platelet-derived growth factor, alpha polypeptide; PDGFA	7p22.3	Potent mitogen for connective tissue cells and exerts its function by interacting with related receptor tyrosine kinases
Platelet-derived growth factor, beta polypeptide; PDGFB	22q13.1	Promotes cellular proliferation and inhibits apoptosis
Platelet-derived growth factor C; PDGFC	4q32.1	Increases motility in mesenchymal cells, fibroblasts, smooth muscle cells, capillary endothelial cells, and neurons
Platelet-derived growth factor D; PDGFD	11q22.3	Involved in developmental and physiologic processes, as well as in cancer, fibrotic diseases, and arteriosclerosis
Insulin-like growth factor I; IGF1	12q23.2	Mediates many of the growth-promoting effects of growth hormone
Fibroblast growth factor I; FGF1	5q31.3	Induces liver gene expression, angiogenesis and fibroblast proliferation
Epidermal growth factor; EGF	4q25	Induces differentiation of specific cells, is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin
Vascular endothelial growth factor A; VEGFA	6p21.1	Is a mitogen primarily for vascular endothelial cells, induces angiogenesis
Vascular endothelial growth factor B; VEGFB	11q13.1	Is a regulator of blood vessel physiology, with a role in endothelial targeting of lipids to peripheral tissues
Vascular endothelial growth factor C; VEGFC	4q34.3	Angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels

Includes, name, cytogenetic location, and biologic activities of platelet growth factors. Furthermore, PRP content other proteins like interleukin-8, macrophage inflammatory protein-1 alpha, and platelet factor-4.