Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat

Figure 3

Increased peptide antiviral potency is associated with increased peptide cationic charge. P4-R5 MAGI cells were exposed to half log concentrations of Tat peptide (TP), three Tat peptide variants (TPvar1-3), decaarginine (R-10), or dextran sulfate (DS) in the presence of HIV-1 strain IIIB for 2 h. Peptide sequences are depicted in Table 1. Reductions in HIV-1 infection (%) were calculated relative to mock-exposed HIV-1 infected cells. The graph represents data from two independent assays in which infections at each concentration were repeated in quadruplicate. Error bars represent standard deviations.