| System/organ | Complications |
| Neurological | Stroke (hemorrhagic or ischemic) | Eyes | Retinopathy | Respiratory | Acute chest syndrome, asthma | Cardiovascular | Cardiomyopathy, left ventricular hypertrophy, pulmonary artery hypertension (PAH), venous thromboembolism | Spleen | Acute splenic sequestration, chronic splenomegaly | Hepato-biliary | Sickle hepatopathy (hepatic sequestration, viral hepatitis, sickle cell intrahepatic cholestasis, cholelithiasis), transfusion iron overload | Renal | Proteinuria, painless hematuria, hyposthenuria, renal impairment/failure | Genital | Priapism | Bones and joints | Acute vaso-occlusive pain crisis, chronic pain, avascular necrosis, aplastic crisis, multifocal osteomyelitis, septic arthritis, fronto-occipital bossing, gnathopathy | Skin | Chronic leg ulcers | Other | Infections, girdle/mesenteric crisis, delayed growth and puberty, jaundice, pallor, depression, anxiety, and poor academic performance |
|
|