Sinonasal Tissue Remodelling during Chronic Rhinosinusitis

Figure 1

Progression of disease in chronic rhinosinusitis. Inflammation observed in acute rhinosinusitis caused by viruses, bacteria, and fungi can resolve to a healthy state or can proceed to CRS if the inflammation persists longer than 12 weeks. The chronic nature of disease induces widespread tissue remodelling of the paranasal sinuses and nasal passage. Unresolved CRS often requires surgical intervention to remove purulent, stagnant mucous, and inflamed tissue.