Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?

Table 1

Implication of TGF-β in peritoneal fibrosis.

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(i) Activates quiescent fibroblasts into myofibroblasts

(ii) Increases fibronectin production by fibroblast and MC

(iii) Induces the expression of connective tissue growth factor (CTGF) by MC

(iv) Stimulates the synthesis of PAI, the natural inhibitor of tPA, contributing to the generation of an antifibrinolytic environment

(v) Increases matrix synthesis and inhibits matrix degradation by decreasing the ratio MMPs/TIMPs

(vi) Induces MMT of MC

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