International Journal of Microbiology

Research Article

Antibacterial and Anticancer Activity and Untargeted Secondary Metabolite Profiling of Crude Bacterial Endophyte Extracts from Crinum macowanii Baker Leaves

Table 5

LC-Q-TOF-MS analysis of crude extracts of C. macowanii leaves and their bacterial endophytes.


Compound name	Rt (min/sec)	m/z	Molecular formula	Reported biological activity	Sample

Melicopicine	5.64	330.1351	C₁₈H₁₉N₁O₅	Antiplasmodial activity [94]	T1
Lycorine	1.92; 13.76; 36.75; 7.23	288.1236	C₁₆H₁₇N₁O₄	Antibacterial cytotoxic and antitumor activities [95]	T1, T7, T9, T10
Angustine	10.35; 19.23; 25.98; 11.07	314.1388	C₂₀H₁₅N₃O₁	Antiproliferative activity [96]	T1, T7, T9, T10
3-O-methyl epimacowine	5.63	288.1586	C₁₇H₂₁NO₃	Anticancer [97]	T7
Crinamidine	17.57; 15.50; 15.44; 6.32	318.1348	C₁₇H₁₉N₁O₅	Antibacterial [21] anticancer activity [98]	T1, T7, T9, T10
Vasicinol	4.18; 21.69; 21.51; 8.91	205.0977	C₁₁H₁₂N₂O₂	Antibacterial activity [99]	T1, T7, T9, T10
Aulicine	1.99	320.1870	C₁₈H₂₅NO₄	Anticancer activity [97]	T9
Powelline	19.14, 14.05, 17.98, 7.43	302.1389	C₁₇H₁₉N₁O₄	Antitumor [100] antibacterial [21]	T1, T7, T9, T10
Brefeldin A	11.52	281.1702	C₁₆H₂₄O₄	Anticancer [101] and antifungal [102]	T10

Note: T1 = C. macowanii leaves, T7 = Bacillus safensis, T9 = Pseudomonas cichorii, T10 = Arthrobacter pascens.