Bacteria in Cancer Therapy: Renaissance of an Old Concept

Table 1

Recent representative preclinical examples of bacteria mediated tumor therapy (BMTT) in vivo from 2012 onwards.

Species	Year	Model	Result	References
C. novyi	2014	Spontaneous, dog	Colonization and prolonged survival	[34]
C. novyi	2015	Glioblastoma, rat	Colonization and prolonged survival	[35]
B. infantis	2013	Bladder, rat	High tumor specificity by engineered strain	[129]
L. monocytogenes	2014	Ovary, mouse	Reprogramming of M2-M, iNOS-mediated tumor cell lysis	[130]
L. monocytogenes; (ANZ-100)	2014	Pancreas, mouse	Prolonged survival	[131]
S. Typhimurium; (A1-R)	2012	Breast, nude mouse	Intravenous administration most effective for tumor targeting	[132]
S. Typhimurium; (A1-R)	2012	Brain, nude mouse	Tumor growth inhibition and prolonged survival	[133]
S. Typhimurium; (A1-R)	2014	Bone metastasis, nude mouse	Inhibition of breast cancer bone metastasis	[47]
S. Typhimurium; (A1-R)	2014	Pancreas, nude mouse	Tumor growth retardation, Α-VEGF supports therapy	[134]
S. Typhimurium; (A1-R)	2015	Ovary, nude mouse	Prolonged survival, less metastasis formation	[51]
S. Typhimurium	2015	Carcinoma (CT26), mouse	Complete tumor rejection in all cases by recombinant strain	[54]
E. coli	2015	Breast (4T1), mouse	Secretion of toxic compound, reduced tumor volume	[113]
La. acidophilus	2014	Carcinoma (CT26), mouse	Increased apoptosis and tumor growth suppression	[135]

C. = Clostridium; B. = Bifidobacterium; L. = Listeria; S. = Salmonella; La. = Lactobacillus; E. = Escherichia.