The Role of IL-17 in the Association between Pneumococcal Pneumonia and Allergic Sensitization

Figure 1

Correlation between IL17 levels in lung homogenates and pneumococcal colony counts in lung. To assess the effect of IL-17 on the risk of pneumococcal pneumonia, the correlation between IL-17 levels in the lung and pneumococcal colony count in the lung was examined. When mice developed pneumococcal pneumonia by bioluminescence or expired, we measured IL-17 levels and pneumococcal colony counts in the lung. As shown in the figure, IL-17 levels in the lung were positively correlated with pneumococcal colony counts in lungs of mice with OVA sensitization/challenge (𝑟=0.32, 𝑃=0.033), but not the controls. OVA sensitization/challenge modified the effect of IL-17 on the risk of pneumococcal pneumonia. log CFU; log₁₀ colony forming units of pneumococci.

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