⁶⁴Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin 𝜶_𝑉𝜷_𝟑 Expression in Human Neuroendocrine Tumor Xenografts

Figure 5

(a)–(c) PET scans showing ⁶⁴Cu-NODAGA-c(RGDyK) uptake in human H727 neuroendocrine tumors in nude mice bearing tumors subcutaneously on the flanks. (a) 1 h post injection of 1.6 MBq ⁶⁴Cu-NODAGA-c(RGDyK) (b) 2 h post injection and (c) 18 h post injection. (d) Time activity curve for ⁶⁴Cu-NODAGA-c(RGDyK) in the H727 tumors calculated as a mean of tracer uptake in left and right tumor at each scan time. Images are 2.5 mm thick slices at the tumor levels; tumors are shown encircled. Scan time: 10 minutes.