Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents
Table 1
Epidemiologic data for 4 critically ill adolescents with recurrent extreme hyperferritinemia.
Patient
Patient
Patient
Patient
Age (years)
15
16
16
19
Gender
Female
Male
Male
Female
Underlying disease
Aplastic anemia
Crohn’s disease, histiocytic sarcoma
X-linked inhibitor of apoptosis deficiency
Mixed phenotype acute leukemia
COVID-19 infection
Yes
No
Yes
No
HSCT
Yes
No
Yes
No
Inflammation
CSS
HLH
HLH
CSS
Immunosuppression
Lymphocytopenia and neutropenia
Lymphocytopenia
Lymphocytopenia and neutropenia
Lymphocytopenia and neutropenia
Nutritional state
Cachexia
Cachexia
Cachexia
Cachexia
First peak in ferritin (ng/mL)/HD
11,856/79
16,809/3
30,164/15
25,108/9
Last peak in ferritin (ng/mL)/HD
22,360/175
36,617/22
>100,000/
36,241/69
Peak in IL-6 (pg/mL)/HD
1,423/178
>4,200/
36,115/99
12,376/67
Peak in CRP (mg/L)/HD
120/97
117/1
NA
>300/
Peak in D-dimer (microg/mL)/HD
11.31/114
17.48/4
>20/
3.77/16
The peak for this biomarker was noted on several different days for this patient. CRP: C-reactive protein, CSS: cytokine storm syndrome, HLH: hemophagocytic lymphohistiocytosis, HD: hospital day, HSCT: hematopoietic stem cell transplant, and NA: not available.