The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis

Table 5

Association between ApaI and FokI genotypes with psoriatic arthritis (PsA) classified according to the HLA-B27 presence and the BASDAI.

HLA-B27 presence
		PsA (N = 13)	Control (N = 10)	P value	Pc	OR (95% CI)
ApaI	AA	1 (0.077)	6 (0.600)	Ref.
	Aa	10 (0.769)	4 (0.400)	0.02	0.04	0.07 (0.01–0.75)
	aa	2 (0.154)	0 (0.000)
BASDAI PsA (N = 40)
		BASDAI < 3.9	BASDAI > 4.0	value	Pc	OR (95% CI)
FokI	FF	2 (0.154)	12 (0.444)	Ref.
	Ff	8 (0.615)	14 (0.519)
	ff	3 (0.231)	1 (0.037)	0.02	0.04	0.25 (0.07–0.91)

All genotypes FokI, TaqI, ApaI, and BsmI were analyzed, but only significant results were shown. Pc = Bonferroni adjustment for multiple testing; N = total number; OR = odds ratio; CI = confidence interval; Ref = reference; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index. Only HLA-B27 positive individuals were analyzed. PsA patients were analyzed, and significance was found in the log-additive inheritance model.