The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis
Table 4
Association between ApaI and spondyloarthritis (SpA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) within and between genders.
SpAa (N = 244)
ASb (N = 174)
PsAc (N = 66)
Controls (N = 197)
value
Pc
OR (95% CI)
ApaI
Female
A/A
48 (0.364)
31 (0.333)
17 (0.436)
32 (0.276)
Ref.
A/a
66 (0.500)
47 (0.505)
20 (0.513)
61 (0.526)
a/a
18 (0.136)
15 (0.161)
2 (0.051)c
23 (0.1980
0.001
0.002
0.16 (0.02–0.47)c
Male
A/A
32 (0.286)
20 (0.247)
12 (0.444)
26 (0.321)
Ref.
A/a
52 (0.464)
38 (0.469)
12 (0.444)
45 (0.556)
a/a
28 (0.250)
23 (0.284)b
3 (0.111)
10 (0.123)
0.018
0.036
2.99 (1.16–7.68)b
ApaI
Female Male
A/A A/A
48 (0.60) 32 (0.40)
32 (0.552) 26 (0.448)
Female Male
A/a A/a
66 (0.559) 52 (0.441)
61 (0.575) 45 (0.425)
Female Male
a/a a/a
18 (0.391) 28 (0.609)a
23 (0.697) 10 (0.303)
Ref.
0.007
0.014
3.58 (1.38–9.25)a
Only significant data are shown. N = total number; OR = odds ratio; CI = confidence interval; Ref = reference; Pc = Bonferroni adjustment for multiple testing. aSpA vs. control; bAS vs. control; cPsA vs. control.
