Evaluation of Inflammatory Markers in Patients Undergoing a Short-Term Aerobic Exercise Program while Hospitalized due to Acute Exacerbation of COPD

Table 1

Comparison of demographic and clinical characteristics at the baseline hospitalization according to control and intervention groups.

N = 26	Control group (N = 13)	Intervention group (N = 13)	value
Woman (%)	69.2	61.5	0.70
Age (y)	69.3 ± 13.5	66.8 ± 9.49	0.58
Smoking (pack-years)	50.0 (31.8–92.0)	46.0 (40.0–68.0)	0.87
LBMI (kg/m^2)	16.0 (14.8–17.0)	15.7 (14.6–17.4)	0.43
BMI (kg/m^2)	23.3 ± 4.69	25.4 ± 5.29	0.41
SGRQ
Symptom (%)	72.8 ± 4.7	79.2 ± 4.5	0.52
Activity (%)	85.8 ± 3.9	91.5 ± 3.7	0.26
Impact (%)	46.5 ± 5.5	60.6 ± 5.3	0.44
Total (%)	62.7 ± 4.5	73.0 ± 4.3	0.53
Anxiety, score	7.4 ± 5.0	8.9 ± 6.9	0.89
Depression, score	5.3 ± 4.4	3.1 ± 3.1	0.04
CRP (mg/dl)	27.2 (7.30–50.52)	8.35 (7.31–29.4)	0.34
TNF-α (mg/dl)	1.57 (1.17–1.77)	1.60 (1.07–1.69)	0.64
IL-6 (mg/dl)	3.68 (1.60–7.10)	2.01 (1.65–5.46)	0.56
FEV1 (L)	0.89 ± 0.32	0.75 ± 0.30	0.14
FVC (%)	60.1 ± 11.8	55.7 ± 17.0	0.55
FVC (L)	1.82 ± 0.60	1.63 ± 0.52	0.28
FEV1/FVC (L pH)	0.49 (0.47–0.56)	0.45 (0.38–0.48)	0.05
PaO2 (mmhg)	7.4 ± 0.0	7.4 ± 0.0	0.37
PaCO2 (mmhg)	56.1 ± 12.7	54.4 ± 14.7	0.83
SaO2 (%)	48.4 ± 5.2	47.7 ± 10.9	0.89
BODE	87.4 ± 4.8	84.8 ± 9.6	0.53
6MWD (m)	5.30 ± 1.88	6.53 ± 1.68	0.08
	219.0 ± 136.8	190.7 ± 94.3	0.34

Values are expressed as mean ± standard deviation or median (quartile 1–quartile 3). LBMI, lean body mass index; BM,: body mass index; SGRQ, Saint George’s Respiratory Questionnaire; CRP, C-reactive protein; TNF-α, tumor necrosis factor alpha; IL-6, interleukin 6; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; PaO2, arterial oxygen pressure; pH, hydrogenation potential; PaCo2, arterial pressure of carbon dioxide; SaO2, arterial oxygen saturation; BODE, body mass index, airway obstruction, dyspnea, and exercise capacity; 6MWT, six-minute walk test; , comparisons evaluated by the t test and Mann–Whitney test.