Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia
Table 3
Subpopulation of lymphocytes in the peripheral blood of tolerant- (T) and susceptible- (S) to-hypoxia Wistar rats in 3, 6, and 24 hours after LPS injection. Data are presented as median (25%, 75%); the statistical significance of differences (p) between tolerant and susceptible rats is determined by the Mann-Whitney test and between different time points after LPS injection by the Kruskal-Wallis method ( = 5 in each group).
Lymphocyte subpopulation
Group
Control group1
LPS injection
p(p<0.05)
3 h2
6 h3
24 h4
CD3+ Т-lymphocytes, % from lymphocytes
T
38.0
42.3
44.6
51.2
(28.4–45.9)
(35.1–51.8)
(25.3–45.2)
(40.0–57.9)
S
53.6
55.8
43.0
46.0
(44.2–54.1)
(48.5–56.4)
(37.9–45.9)
(40.2–51.5)
p
0.14
0.25
0.33
0.38
CD3+CD4+ Т-helper cells, % from T-lymphocytes
T
57.5
46.1
20.3
42.2
0.021-3
(49.0–66.3)
(42.0–51.5)
(16.4–21.2)
(29.8–50.4)
S
29.8
44.8
22.1
46.3
(23.2–34.4)
(34.3–61.0)
(21.3–23.8)
(43.1–50.5)
p
0.06
0.75
0.33
0.51
CD3+CD8+ cytotoxic Т-lymphocytes, % from T-lymphocytes
T
40.8
52.7
76.6
54.6
0.021-3
(31.8–49.3)
(47.7–57.2)
(74.0–82.6)
(46.3–67.7)
S
69.5
53.6
73.8
52.9
(63.5–76.1)
(37.8–62.9)
(69.4–76.8)
(46.2–54.6)
p
0.06
0.75
0.62
0.66
CD4+CD25+ Foxp3+ regulatory Т-cells, % from T-helpers